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Thanks to breakthroughs in medical research, people treated for cancer are living longer than ever. At The Breast Center at Montefiore Nyack Hospital, researchers conduct clinical trials to identify new ways to prevent, detect or treat breast cancer. They also look for ways to improve patients’ quality of life. Researchers test new drugs, surgical procedures and devices, as well as new ways to use existing treatments, to answer questions about their safety, benefits and side effects.

If you participate in a clinical trial, you might receive a new treatment, and your quality of life and/or medical outcome might improve as a result. In a randomized clinical trial, your chance of receiving the experimental treatment is about 1 in 2 or possibly 2 in 3. If you don’t receive the treatment that’s being tested, you’ll receive today’s standard treatment. By participating in a clinical trial you’ll help improve the care of future patients.

Clinical trials have eligibility requirements, which may include your age, gender, the type and stage of cancer, other medical conditions and treatment history. If your doctor thinks you’re a good candidate, he or she will explain the study, what its benefits and risks are and possible side effects of the experimental treatment.

• ABC Trial: Researchers are studying how well aspirin works in preventing cancer from returning in women with HER2-negative breast cancer after chemotherapy, surgery and/or radiation therapy.
• Capivasertib+Paclitaxel: This study is investigating the safety and effectiveness of an intravenous drug (Paclitaxel) and an oral drug (Capivasertib) in patients with locally advanced or metastatic, triple-negative breast cancer.
• FLEX: Researchers will gather genomic and clinical information on 10,000 breast cancer patients and follow them for 10 years to identify new gene associations that may indicate whether cancer will spread to other parts of the body.
• S1501: This study will determine how well the beta blocker drug carvedilol works in preventing cardiac toxicity in patients with HER-2 positive breast cancer that has spread to other parts of the body.
• Xenera: This study is investigating whether the drug xentuzumab (an intravenous infusion), in combination with two other drugs (everolimus and exemestane), is more effective than everolimus and exemestane alone in women with hormone receptor positive, HER-2 negative breast cancer that has spread.

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